Scharp on inconsistent concepts and their engineered replacements, or: Can we mend these broken things?

Kevin Scharp’s influential work on the alethic paradoxes combines an extensively developed inconsistency theory with a substantial conceptual engineering project. I argue that Scharp’s inconsistency theory is in tension with his conceptual engineering project: the inconsistency theory includes an account of concepts that implies that the conceptual engineering project will fail. I recommend that Scharp revises his account of concepts, and show how doing so allows him to resolve the tension. The discussion is important for ongoing work on conceptual engineering. Firstly, it is important to get clear on whether Scharp’s conceptual engineering project is—or could be—successful. Secondly, the issues discussed herein may generalise to other conceptual engineering projects, such as explication and ameliorative projects. In particular, the discussion has implications for how conceptual engineers can think about concepts and their relation to how we use words

British Sikhs in complementary schooling: the role of heritage language proficiency and ‘culture learning’ in ethnic identity and bicultural adaptation

While the debate regarding bilingual benefits persists within the cognitive sciences, education research has documented various functions that heritage languages (HL) serve their speakers through bicultural adaptation. The present study adopted a mixed-methods approach to gauge HL proficiency and use, cultural participation and ethnic and mainstream identities, and to examine multiple perspectives on HL learning with complementary schooling (CS) among British Sikhs. Seventy-four 6- to 15-year-olds completed scales for perceived oral and literate abilities, language use across contexts, British and Sikh identifications, and participation in cultural activities. Children filled in open-ended items, while parents and teachers discussed in interviews and focus groups, their motivations for HL learning and CS experiences. The majority of children self-reported ‘good’ proficiency, which differed between generations as impacted by home use and was associated with cultural participation and Sikh identification. Most children referred to practical utility while most parents regarded culture retention as the dominant motivation for HL learning. Teachers discussed how teaching beyond the second generation and language shifts presented both challenges and opportunities. Still, all parties corroborated on the pertinence of HL maintenance as facilitated by CS through ‘culture learning’ towards a strong ethnic identity and bicultural adaptation

Updated recommendations for HER2 testing in the UK

This paper serves to update previously published guidance on rationale and methodology for HER2 laboratory testing following the recommendation for the use of HER2 targeted treatment in the management of advanced breast cancer in the UK. Emphasis is placed on the standardisation of methodology and assessment and strategies to achieve high quality performance. A two phase testing algorithm based on first line immunocytochemistry evaluation and second line fluorescence in situ hybridisation assessment of borderline cases is recommended. To ensure maintenance of expertise, an annual caseload volume of at least 250 cases is recommended for laboratories providing a testing service

Length-weight relationships of two conservation-concern mahseers (Teleostei: Cyprinidae: Tor) of the river Cauvery, Karnataka, India

Length-weight (LW) relationships are presented for two conservation-concern species of mahseer (Tor spp.) from southern India’s river Cauvery. Constructed from angler catch data, these are the first available LW relationships for the Critically Endangered Tor remadevii and the non-native and locally invasive Tor khudree. For T. remadevii, the value of b, the allometric parameter, was 2.94 (95% CI: 2.75–3.14) and was not significantly different from 3.0, indicating isometric growth (t = 0.61, P = 0.54). For T. khudree, b was greater at 3.18 (95% CI: 3.01–3.38), but with this also not significantly different from 3.0 (t = 1.91, P = 0.06). Outputs are discussed with reference to species conservation and recreational catch-and-release fisheries

Are well‐intended Buddhist practices an under‐appreciated threat to global aquatic biodiversity?

Abstract 1. The inherently pro‐conservation and humane Buddhist practice of ‘live release’, entailing the release into the wild of creatures destined for slaughter, poses potentially significant conservation consequences if inappropriate, invasive species are procured for release. 2. This article collates evidence, citing one legal case and other examples, about the risks of the live release of potentially invasive aquatic species that may result in serious, possibly irreversible, conservation threats to aquatic biodiversity and natural ecosystems, with ensuing adverse ecological and human consequences. 3. It is essential that practitioners are aware of these risks if their actions are not to work diametrically against the pro‐conservation and humane intents of the practice. 4. Ensuring that live release occurs safely necessitates raising awareness, with guidance informed by science, to ensure that good intentions do not result in perverse, environmentally destructive outcomes. 5. We propose four simple principles to achieve this, for dissemination to the global adherents of these otherwise entirely laudable practices

Artesunate reduces but does not prevent posttreatment transmission of Plasmodium falciparum to Anopheles gambiae.

Combination therapy that includes artemisinin derivatives cures most falciparum malaria infections. Lowering transmission by reducing gametocyte infectivity would be an additional benefit. To examine the effect of such therapy on transmission, Gambian children with Plasmodium falciparum malaria were treated with standard regimens of chloroquine or pyrimethamine-sulfadoxine alone or in combination with 1 or 3 doses of artesunate. The infectivity to mosquitoes of gametocytes in peripheral blood was determined 4 or 7 days after treatment. Infection of mosquitoes was observed in all treatment groups and was positively associated with gametocyte density. The probability of transmission was lowest in those who received pyrimethamine-sulfadoxine and 3 doses of artesunate, and it was 8-fold higher in the group that received pyrimethamine-sulfadoxine alone. Artesunate reduced posttreatment infectivity dramatically but did not abolish it completely. The study raises questions about any policy to use pyrimethamine-sulfadoxine alone as the first-line treatment for malaria